Pair Name	Lycopene, Anti-PD-1 antibody
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Immunomodulatory
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	CXCL10	KEGG ID N.A.
	Up-regulation	Expression	CXCL9	KEGG ID N.A.
	Down-regulation	Expression	DNMT3A	KEGG ID N.A.
	Up-regulation	Expression	IFNG	hsa3458
	Up-regulation	Expression	IRF1	hsa3659
	Up-regulation	Expression	IRF7	KEGG ID N.A.
	Up-regulation	Phosphorylation	JAK2	hsa3717
	Down-regulation	Expression	PD-L1	KEGG ID N.A.
	Up-regulation	Phosphorylation	STAT3	hsa6774
In Vitro Model	3LL	Malignant tumors of the mouse pulmonary system	Mus musculus (Mouse)	CVCL_5653
In Vivo Model	Lewis lung carcinoma (LLC) cells (1×10⁶) were injected in the rear flak of C57BL/6 mice
Result	lycopene promoted anti-PD-1 therapeutic efficiency of lung cancer by promoting IFNγ-expressing CD8+ cells infiltrated in tumor tissues and increasing IFNγ expression in tumor cells.